71. Grafting of ovarian tissue in a non-human primate model

Ethics: Moral issues of human-non-human primate neural grafting.

I f human neural stem cells were implanted into the brains of other primates what might this do to the mind of the recipient? Could such grafting teach us anything of value for treatment of neurological injury and disease? Could we change the capacities of the engrafted animal in a way that leads us to reexamine its moral status? These questions have gained significance since publication of res...

The Non-human Primate as a Model of Human Parkinsonism

Lesion kinetics in a non-human primate model of endometriosis.

BACKGROUND Endometriosis is a common cause of pelvic pain and infertility in women of reproductive age. It is characterized by the presence of endometrial tissue outside the normal location, predominantly in the pelvic peritoneum causing severe abdominal pain. However, the severity of the symptoms of endometriosis does not always correlate with the anatomic severity of the disease. This lack of...

O-17: Human Ovarian Tissue Xenotransplantation Application in Drug Discover

Background: Reproductive toxicity studies (RTS) represent an important part of pre-clinical safety evaluation of any drug development process for human consumption. It is mandatory requirement that RTS must be completed before any drug can be administered to women of childbearing age. Therefore, at first segment of toxicity check the toxic effect of the drug on fertility must be tested on non-c...

A Non-Human Primate Model of Severe Pneumococcal Pneumonia

RATIONALE Streptococcus pneumoniae is the leading cause of community-acquired pneumonia and infectious death in adults worldwide. A non-human primate model is needed to study the molecular mechanisms that underlie the development of severe pneumonia, identify diagnostic tools, explore potential therapeutic targets, and test clinical interventions during pneumococcal pneumonia. OBJECTIVE To de...